Hemophilia B

What is Hemophilia B?

Hemophilia B is a genetic bleeding disorder characterized by a deficiency in clotting factor IX, a protein crucial for blood clotting.

This deficiency impairs the blood's ability to clot effectively, leading to prolonged bleeding episodes even from minor injuries. It is inherited in an X-linked recessive pattern, primarily affecting males.

Side Effects of Hemophilia B

The primary concern for individuals with Hemophilia B is the increased risk of bleeding. Common symptoms include:

• Prolonged bleeding: Even a small cut or injury can result in prolonged bleeding.
• Easy bruising: Individuals may bruise easily due to minor trauma.
• Joint pain and swelling: Bleeding into joints, especially knees, ankles, and elbows, can cause pain, stiffness, and swelling.
• Excessive bleeding: Internal bleeding can occur, which may be life-threatening if not promptly treated.

How is Hemophilia B Diagnosed?

Diagnosis typically involves:

• Medical history: Discussing symptoms and family history of bleeding disorders.
• Blood tests: Testing for clotting factors, particularly factor IX activity levels.
• Genetic testing: To confirm the specific genetic mutation causing Hemophilia B.

Potential Treatment of Hemophilia B

Treatment aims to prevent and manage bleeding episodes effectively. Options include:

• Replacement therapy: Infusing clotting factor IX concentrates to restore normal clotting function.
  
• Prophylactic treatment: Regular infusions to prevent bleeding episodes.
• On-demand treatment: Infusions administered at the onset of bleeding symptoms.
• Gene therapy: Experimental treatments aiming to correct the genetic defect causing Hemophilia B.

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