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What is Iodine-123 (I-123) Scan (Thyroid Imaging)?

An Iodine-123 (I-123) scan, also known as a thyroid imaging scan, is a diagnostic procedure used to evaluate the structure and function of the thyroid gland. It utilizes a radioactive form of iodine, I-123, which is taken up by the thyroid gland.

This scan is particularly useful in detecting abnormalities such as nodules, tumors, or overactive thyroid tissue.

Side Effects of Iodine-123 (I-123) Scan (Thyroid Imaging)

Iodine-123 used in the scan emits a small amount of radiation, which is generally safe but may pose a slight risk, especially to pregnant women. Patients may experience mild discomfort or allergic reactions if they have sensitivity to iodine. However, serious side effects are rare.

How is Iodine-123 (I-123) Scan (Thyroid Imaging) Diagnosed?

The procedure begins with the patient ingesting a small amount of I-123, either in pill or liquid form. Over the next few hours, the radioactive iodine is absorbed by the thyroid gland.

After a waiting period to allow the iodine to localize in the thyroid, imaging is performed using a special gamma camera. This camera detects the radiation emitted by the I-123 and creates detailed images of the thyroid gland.

Potential Scan of Iodine-123 (I-123) Scan (Thyroid Imaging)

The Iodine-123 scan can reveal several conditions:

  • Thyroid Nodules: Identifying whether nodules are hot (active and producing excess hormones) or cold (non-functional).
  • Thyroid Cancer: Detecting the presence, location, and extent of thyroid cancer.
  • Thyroiditis: Assessing inflammation of the thyroid gland.
  • Graves' Disease: Evaluating the activity and size of the thyroid gland in cases of hyperthyroidism.


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