Paget's Disease

What is Paget's Disease?

Paget's Disease of bone is a chronic disorder characterized by abnormal bone remodeling, leading to weakened and deformed bones. It typically affects older adults and often involves specific areas such as the pelvis, spine, skull, and long bones of the legs.

Side Effects of Paget's Disease

The most common symptoms include bone pain, deformities, and fractures due to weakened bones. Patients may experience joint pain, nerve compression, and in severe cases, hearing loss or headaches if the skull is affected.

How is Paget's Disease Diagnosed?

Diagnosis involves a combination of medical history, physical examination, imaging tests such as X-rays, bone scans, and sometimes MRI or CT scans to assess the extent of bone involvement.

Blood tests measuring specific markers of bone turnover can also aid in diagnosis.

Potential Treatment of Paget's Disease

Treatment aims to relieve symptoms, prevent complications, and normalize bone structure and function. Options may include:

• Medications: Bisphosphonates, such as alendronate or zoledronic acid, are commonly prescribed to inhibit bone breakdown and reduce pain.
• Calcitonin: This hormone can help regulate bone turnover and reduce pain in some cases.
• Surgery: Reserved for severe cases where complications like fractures or nerve compression require surgical intervention to stabilize bones or relieve pressure.
• Physical Therapy: To improve mobility and strengthen muscles around affected joints.
  

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